Autologous Exosome Procedures for Joint & Soft Tissue Support in London
Why Choose Rejuvence Clinic for Autologous Exosome Procedures?
At Rejuvence Clinic, we provide advanced autologous biologic procedures designed to support joint and soft tissue health. Our approach centres on the ExoSmart™ autologous exosome concentration system, supported by the Angel Arthrex blood processing platform, and delivered exclusively by a senior Orthopaedic Surgeon.
These procedures are commonly explored by individuals seeking non-surgical, minimally invasive biologic support options for joints, tendons, ligaments, and muscle structures, including the knees, hips, shoulders, and elbows.
Where clinically appropriate, more than one anatomical area may be addressed during a single visit.
All procedures are performed under real-time ultrasound guidance to support accurate placement and procedural precision.
The Angel Arthrex System: Advanced Autologous Blood Processing
The Angel Arthrex System is a hospital-grade platform used to process autologous blood-derived biologic material under sterile, controlled conditions.
Unlike basic centrifuge devices, the Angel Arthrex system allows:
- Precise control of cellular composition
- Consistent processing suitable for larger-volume applications
- Closed-system handling designed to maintain biologic integrity
This platform is widely used in orthopaedic and surgical environments internationally and provides the foundational biologic material used within our autologous exosome procedures.
ExoSmart™ Autologous Exosome Concentration System
ExoSmart™ is an advanced medical device designed to isolate and concentrate autologous extracellular vesicles (exosomes) from a patient’s own blood-derived sample.
Exosomes are nanoscale vesicles naturally involved in cellular communication. When concentrated, they form part of a biologic solution that may be selected to support joint and soft tissue environments as part of a clinician-led procedure.
At Rejuvence Clinic, ExoSmart™ represents the core technology underpinning our autologous exosome procedures.
Common Areas Where Procedures May Be Considered
Knee
Autologous exosome procedures may be discussed for individuals experiencing joint stiffness, mechanical symptoms, or activity-related discomfort.
Hip
Selected hip joint or peri-articular soft tissue concerns may be assessed for procedural suitability following evaluation.
Shoulder
Procedures may be considered for shoulder-related soft tissue structures based on clinical findings.
Elbow
Persistent elbow discomfort or tendon-related symptoms may prompt discussion of biologic procedural options.
What Distinguishes ExoSmart™ Scientifically and Technologically?
ExoSmart™ utilises precision ultrafiltration technology to concentrate extracellular vesicles while reducing excess plasma fluid and non-essential proteins.
Key technical characteristics include:
High-efficiency vesicle concentration through controlled filtration
Consistent particle sizing aligned with extracellular vesicle profiles
Rapid processing suitable for same-session procedures
CE-MDR certified medical device
Enhance skin firmness and elasticity
Manufactured under ISO 13485 quality standards
Independently characterised using established laboratory methods
This process is designed to produce a high-purity, autologous exosome concentrate suitable for musculoskeletal and soft tissue procedural use.
How Autologous Exosome Procedures Are Used in Musculoskeletal Care
At Rejuvence Clinic, autologous exosome procedures may be considered across a broad range of musculoskeletal support applications, including joints and surrounding soft tissues.
These procedures are not presented as cures, disease-modifying treatments, or replacements for surgery. Instead, they may be explored by individuals seeking biologic, clinician-delivered procedural options within a wider care strategy.
Suitability is determined following consultation, imaging where appropriate, and clinical assessment.
For Those Interested in the Science Behind Exosomes
Exosomes are extracellular vesicles naturally present in blood and tissues. They contain signalling molecules such as proteins, lipids, and nucleic acids that play a role in cell-to-cell communication.
The ExoSmart™ system concentrates these vesicles using a controlled ultrafiltration process. The resulting biologic material is characterised using established laboratory techniques, including nanoparticle tracking analysis and flow cytometry.
Research into extracellular vesicles is an evolving field within orthopaedics, sports medicine, and biologic sciences.
Because the procedure uses autologous material derived from your own blood, it may be possible to address more than one anatomical area during a single appointment, subject to clinical judgement.
All injections are performed under ultrasound guidance to support accurate placement within joints or surrounding soft tissues.
Rejuvence Clinic exclusively utilises autologous exosomes, derived from the patient’s own blood sample.
This approach avoids regulatory and safety concerns associated with donor-derived, synthetic, placental, or imported exosome products. All procedures are delivered in line with UK clinical governance standards
In some cases, autologous exosome procedures may be combined or staged with hyaluronic acid joint injections, such as Ostenil Plus.
Hyaluronic acid is commonly used to support joint lubrication and comfort and may be discussed as part of a personalised care plan.
Autologous exosome procedures are delivered within a regulated UK medical framework, overseen by the Care Quality Commission (CQC) and the Medicines and Healthcare products Regulatory Agency (MHRA).
Rejuvence Clinic operates in accordance with these regulatory expectations, with a focus on patient safety, transparency, and clinician accountability.
The MHRA regulates medicines, advanced therapies, and medical devices in the UK.
Autologous biologic procedures that involve minimal manipulation of a patient’s own blood-derived material, prepared and used within the same clinical setting, may fall outside the scope of Advanced Therapy Medicinal Products (ATMPs), provided specific criteria are met.
At Rejuvence Clinic:
- CE-MDR certified medical devices are used exclusively
- Biologic material is prepared and used on the same day
- No donor-derived, expanded, stored, or imported biologics are used
- No claims of disease treatment, cure, or regeneration are made
The Angel Arthrex and ExoSmart™ systems are medical devices, not medicinal products, and are operated strictly within their intended purpose.
The CQC does not approve or endorse individual treatments. Instead, it regulates how care is delivered.
For biologic procedures, the CQC expects:
- Clear scope of practice and clinician responsibility
- Appropriate patient selection and consultation
- Transparent discussion of evidence, limitations, and uncertainty
- Robust informed consent processes
- Safe environments, infection control, and equipment governance
All autologous exosome procedures at Rejuvence Clinic are delivered in line with these expectations.
Patients considering autologous exosome procedures at Rejuvence Clinic can expect:
- Clinician-led assessment and decision-making
- Honest discussion of potential benefits and limitations
- No guarantee of outcomes
Full transparency regarding alternatives and uncertainties
Why Choose Rejuvence Clinic?
Senior Orthopaedic Surgeon-led procedures
Ultrasound-guided injections for accuracy and safety
CE-marked, hospital-grade biologic systems
Individualised care plans for single or multiple joint areas
Ethical, compliant, evidence-informed approach
Ready to Explore Your Options?
If you are considering autologous exosome procedures for joint or soft tissue support, our team will guide you through a comprehensive consultation.
